Which supplements help build muscle?
Creatine, plus enough protein. Those two have the best evidence for building muscle. But in trials, extra protein stopped adding lean mass past one number, and BCAA pills alone aren’t shown to build muscle.
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Which supplements actually help build muscle?
Creatine first. A sports nutrition society, the ISSN, calls creatine monohydrate the most effective supplement for adding lean mass during training.
Protein comes next, but only up to a point. A protein powder is food in a tub. It helps when your meals leave you short.
Neither works without lifting. The NHS says to work all the major muscle groups on at least 2 days a week.
| Supplement | What trials found | Worth it? |
|---|---|---|
| Creatine monohydrate | About 1.1 kg more lean mass than lifting alone, in adults under 50. | Yes, 3 to 5 g a day. |
| Protein powder | About 0.3 kg more. On average, no extra gain past about 1.6 g of protein per kg a day. | Only to fill a gap. |
| Essential amino acids (EAAs) | Needed to build muscle. Whole protein gives you all of them. | Not as pills, if you eat enough protein. |
| BCAAs | Not shown to build muscle on their own. | No. |
| HMB | No clear gain in muscle or strength in 18 to 45 year olds. | No. |
| Beta-alanine | Helps hard efforts of 1 to 4 minutes. Can cause tingling. | For performance, not muscle. |
Sources: Desai 2024; Morton 2018; ISSN protein; Wolfe 2017; Jakubowski 2020; ISSN beta-alanine
Your next move: check how much protein you eat, then add creatine. For the training side, see how to build muscle.
Does creatine build muscle?
Yes, a little, if you lift. Across 12 trials in adults under 50, creatine plus weights added 1.14 kg more lean mass than weights alone. It also cut fat by about 0.7 kg.
Lean mass is everything that isn’t fat, so part of that gain is water. Creatine helps muscle hold a little water, and weight gain is its only regular side effect.
Sources: Desai 2024; Morton 2018
The two numbers come from different trials, so compare them loosely.
Take 3 to 5 g a day. That raises your muscle stores over 3 to 4 weeks, so you don’t need to load. Buy plain monohydrate: see the best creatine to buy and how much creatine per day.
Over 55? A UK health claim says 3 g a day can boost the strength gains from weight training. That’s training at least 3 times a week for several weeks, with the load going up over time.
Do you need protein powder to build muscle?
No, not if food already gives you enough. Across 49 trials, protein supplements added about 0.3 kg of lean mass to what lifting built. They also added about 2.5 kg to the most people could lift once.
Here’s the number from the top: about 1.6 g of protein per kg of body weight a day. Past that, extra protein added no more lean mass on average.
For someone who weighs 75 kg, that’s 120 g a day. The ISSN gives 1.4 to 2.0 g per kg for most people who exercise. It suggests doses of 20 to 40 g every 3 to 4 hours.
Where to spend your effort first
- 1
Lift
All the major muscle groups, at least 2 days a week.
- 2
Eat protein
About 1.6 g per kg a day, from food first.
- 3
Add creatine
3 to 5 g a day of plain monohydrate.
- 4
Top up
Protein powder only if food falls short.
Sources: NHS; Morton 2018; ISSN creatine
Count what you eat for 3 days before you buy a tub. See how much protein per day and the best protein powder for muscle.
What are the best amino acids for muscle growth?
The essential ones. Amino acids are the building blocks of protein. The ISSN says it’s the essential amino acids (EAAs) that switch on muscle building.
You don’t need them as pills. Eggs, milk, whey, soy and beef can do as well or better than loose amino acids with the same amount of EAAs.
BCAAs are three of the EAAs: leucine, isoleucine and valine (see EAAs vs BCAAs). One expert review found the claim that BCAAs alone switch on muscle building in people is unwarranted.
So spend the money on protein food or a full protein powder instead.
Are muscle mass builders worth it?
Most mass gainers are protein powder with added carbs. They add calories, which normal meals can do too. Check the protein per serving, as you would on any powder.
Be wary of anything that promises steroid-like gains. UK Anti-Doping warns that supplements can be contaminated with banned substances, and labels can be wrong.
Anabolic steroids are prescription-only medicines. The NHS lists serious side effects, including heart attack or stroke, liver or kidney problems and infertility in men. They’re addictive too.
Before you buy a muscle supplement
- Work all the major muscle groups on at least 2 days a week.
- Count your protein for 3 days and compare it with about 1.6 g per kg of body weight.
- Choose plain creatine monohydrate and take 3 to 5 g a day.
- Buy protein powder only to fill a gap your food leaves.
- Skip BCAA and HMB products, and anything that promises steroid-like gains.
- Ask your doctor first if you have kidney disease and want to try creatine.
Sources: NHS; Morton 2018; ISSN creatine; UKAD
Tempted by a testosterone booster? See what testosterone boosters actually do.
When to speak to a GP
Book an appointment if:
- You have kidney disease and want to try creatine. The ISSN suggests you ask your doctor first, though it found no strong evidence of harm.
- You take anabolic steroids and think you may be addicted. The NHS says to see a GP.
- You worry a lot that you’re not big or strong enough. Some people with body dysmorphic disorder (BDD), where you worry about flaws others barely notice, take steroids for this. The NHS says to see a GP if you think you might have BDD.
Never stop or change a prescribed medicine without your prescriber.
Worried creatine will upset a kidney blood test? See does creatine raise creatinine.